Pyritinol was first created in 1961 by bonding two Pyridoxine (Vitamin B6) compounds together. Since the 1970’s, Pyritinol has been prescribed in countries around the world for cognitive and learning disorders. This semi-synthetic supplement is available in the United States and several other countries OTC.
There have been few studies completed on Pyritinol to prove its effectiveness as a nootropic. Nonetheless, Pyritinol users validate it to have cognitive benefits and incorporate it into their daily nootropic stacks.
There have been several studies showing Pyritinol to be effective in overall reaction times and “mental agility”. These studies did not show Pyritinol to be effective for increasing learning and memory in humans. This does not mean it is totally ineffective in these areas as the data is very limited. One study did show Pyritinol to greatly improve choline uptake and overall Actelycholine levels in rats.
The study data on Pyritinol is very thin and therefore it cannot be proven to be effective or ineffective for increased mental preformance or memory. Many individual user experiences have claimed Pyritinol to be effective in overall mental performance and mood but like any supplement or drug, results will vary largely from user to user.
Pyritinol vs Pyridoxine (Vitamin B6)
It would be common sense to assume the effects of Pyritinol and Pyridoxine would be very similar. If you are unfamiliar with Pyridoxine, it is more commonly referred to as Vitamin B6 and it is an important nootropic vitamin in our bodies.
Pyridoxine is essential in the production of the important neurotransmitters: Serotonin, Dopamine, Epinephrine and Glutamate. These neurotransmitters are essential in every cognitive function and this is this is why Pyridoxine can be considered a nootropic vitamin with possible anti-depressant and anxiety properties.
Pyritinol has a similar method of action to Pyridoxine but with enhanced effects. Users of Pyritinol, claim it makes reaction times and overall thinking more efficient. Others have claimed Pyritinol to be an anti-depressant and anxiolytic substance.
Pyritinol & Dopamine
Some scientists and speculators have pointed Pyritinol’s attention and focus boosting benefits to be a cause of increased Dopamine levels. It is quite possible many of the nootropic benefits are indeed caused by increased Dopamine levels, especially in those who are deficient in the chemical.
The Dopamine neurotransmitter is important in cognitive areas such as: learning, working memory, focus, motivation and reward just to name a few. Vitamin B6 is a precursor to Dopamine but it has to travel through several transformations before it converts fully into Dopamine. Pyritinol is a more efficient precursor and therefore a more potent Dopaminergic. Combing Pyritinol with another Dopaminergic may increase these positive benefits but there is limited data in this area.
Dopamine is just one of the neurotransmitters theorized to cause Pyritinol’s nootropic benefits. The other neurotransmitter efficiency increased by Pyritinol could also be at work. It is also quite possible the Acetylcholine and choline uptake increased in rats could be mimicked in humans but there needs to be more data on Pyritinol in this area before a conclusion is made.
Sulbutiamine & Pyritinol
Sulbutiamine and Pyritinol are said to work very well together. The synergistic effect between the two has a very high nootropic and mood increasing benefit. If you have tried one or the other and you like the effects, try stacking the two together to get optimal results.
Some have compared the combination of Sulbutiamine and Pyritinol to be like MDMA but without the stimulant effects. Others see the stack as the only nootropic stack they need. It its recommended and much safer to try each supplement by itself first before stacking the two. This will decrease the chance of possible side effects and negative interactions.
Pyritinol Side Effects
- Loss of Appetite
- Skin Itching
Warning: There were some reports of an allergic reaction to Pyritinol. These reports are very very rare and not fully backed up medically but it always important to evaluate the risks before taking any supplement. This so called “allergic reaction” could be life threatening so minimize risk by taking lower dosages first before increasing intake. Speak with your doctor before starting Pyritinol if you are on other medications.