a) The Synthesis
Corneliu E. Giurgea, a Romanian psychologist and chemist formulated and synthesized Piracetam in 1964. It is a compound known to conform to the characteristics of both a nootropic and neuroprotective agent. It is prepared by condensing 2-pyrrolidinone with ethyl chloroacetate which then is converted into an amide with ammonia.
Pharmacologically, as a neuroprotective agent, it is known to prevent damage to the brain/spinal cord from convulsions, ischemia, stroke, or trauma. The mechanism of action could be various but in effect, they either directly or indirectly minimize the damage produced by the excitatory amino acids. As nootropic agents, they are used to enhance learning, and or memory. In particular, they are recommended to reduce the cognitive deficits associated with dementia, i.e. loss of memory. It needs to be kept in mind that no nootropic drugs have been accepted for general use and they are still at an experimentary stage.
Piracetam is a racetam supplement and gets absorbed into the system very quickly. It has 100% bioavailability when taken in the form of capsules, powders, solutions or tablets. This racetam is excreted more or less, completely through the urine. It is used in renal dialysis and has the ability to cross placental barrier and diffuse itself across membranes. It is also naturally exerted in human breast milk so avoid using if you are pregnant.
Piracetam is proving its efficacy over a period of time on treating disorders relating to
- neurodegenerative diseases
- stroke /ischemia
While administration of Piracetam did not exhibit long-term benefits for the treatment of mild cognitive disorders, its neurprotective effect was demonstrated in its efficacy during coronary bypass surgery. It was also found to be effective in the treatment of cerebrovascular disorders. When its efficiency between the treatment for enhancing memory and reducing anxiety and depression was compared, it was found to be effective much later. As a supplement, it is useful for patients suffering from myoclonus epilepsy and tardive dyskinesia. When supplemented with a vasodilator drug, it was found to improve cognitive disabilities.
Some people also believe Piracetam can improve creativity. They believe this because it is reported to have a unique ability to increase the contact between the left and right hemispheres of the brain. This is understood to improve creativeness. The effect of improving the memory helps in the users’ ability to save and store more information in the brain. Piracetam is not a tonic drug, yet it has the effect of working inside our ion channels to improve blood flow which promotes ‘membrane permeability’ to particular fragments of the brain. In short, the positive effects of Piracetam could be compared to snowballs that build off one another to improve the cognitive abilities over a long period.
Piracetam is currently available in some countries without a prescription. Sometimes it can be mixed with supplemental constituents like: Huperzine A., Choline, Alpha-Lipoic Acid and complex B vitamins. This is believed to enhance the nootropic effects of this racetam but there is little hard evidence to back this up and some scientists dispute it.
Piracetam is contradicted in patients with cerebral hemorrhage, end stage renal diseases. It should also not be used by those suffering from Hunlington Chorea. The safety of its usage during pregnancy and lactation has not been conclusively established.
It is known to produce adverse reaction in those suffering from gastrointestinal disorders, immune system disorders, nervous system disorders including headache, insomnia, somnolence, psychiatric disorders as agitation, confusion, skin disorders as dermatitis, pruritus etc
Some common side effects include:
The side effects are usually dosage dependent and some users may be more sensitive than others. It is recommended to consult a doctor before you take Piracetam.
Available in tablets, liquid, and powder. Advance Nootropics currently only carries powder form as Piracetam is needed in higher doses. Reports have shown dosages from .01/g – 10g being used. We recommended to not go higher than 1g per dose to avoid complications. Be responsible, and read the directions.
Shelf life & Storage
Currently, the shelf life of our powdered Piracetam is 3 years. Store in a cool dry place and avoid contamination by keeping the package sealed. Keep package below 25 degrees C.