a) The synthesis
Oxiracetam belongs to the ‘racetam’ family and was developed as an alternative to Piracetam and Aniracetam. It was first introduced in Italy by a pharmaceutical company, in 1988. SmithKline Beckman Corporation was the original rights holder of it in the USA. Several pharmaceutical companies were involved in the research and development to uncover the potential impact of the drug on specific conditions. SmithKline was reported to be researching its benefits in the prevention and treatment of Alzheimer’s disease.
Oxiracetam is synthesized according to the chemical formula C6H10N2O3. It is known to be chemically weaker than Piracetam but some users feel it has more pronounced effects. Even though it may be weaker chemically, many people prefer this memory supplement over its counter-part nootropics. This could be due to the fact that Oxiracetam is much more efficient in its mechanisms of action. Unfortunately, all of the mechanisms of action are not fully understood at this time.
Pharmacologically, as with Piracetem, Oxiracetam is also known to facilitate in the enhancement of memory and in particular, reduce the cognitive deficits associated with dementia. Oxiracetam has an added benefit of increasing relaxation and reducing depression and anxiety in some users.
When defined in a loose manner, this nootropic is also considered as a psychotropic agent which include: antidepressive, hallucinogenic, tranquilizing, anti-psychotic, and anti-anxiety effects.
Even though the mechanism of action of Oxiracetam is not fully understood yet, what we do know is that it acts as a ‘positive allosteric modulator’. Positive allosteric modulators indirectly contribute to overall receptor activity in the brain.
Benefits of Oxiracetam
- An improved memory, especially in the elderly
- A heightened concentration
- Superior auditory and color perception
- An improvement in mood
- Better and deeper sleep and consequently more energy during the day
- Increased levels of motivation due to reduction in overall fatigue
- Lowered anxiety and an improved feeling of relaxation
- Increase in the attention span
- A higher level of motivation and energy
- Less toxic and hence lower the side effects
In one study, participants who were taking Valium were given a dose of Oxiracetam. The next day, the participants reported an increase in their vigilance and alertness as compared to their experiences with just the Valium. In short, this nootropic supplement is known to provide an improved feeling of general well being.
Oxiracetam is now available in some countries without a prescription. As a memory supplement, it is known for its brain boosting effects. It is also known to give superior results when mixed with one or more constituents such as, Acetyl-L-Carnitine, Ginkgo Biloba Extract, Alpha-Lipoic Acid (ALA), Huperzine A, N-Acetyl-L-Cysteine, (NAC), Phosphatidyl Serine, etc.
Between Piracetam and Oxiracetam, Oxiracetam is reported to have fewer side effects. Nonetheless, it can still cause the following.
- Light headedness
- Mild depression
- Pregnant and expectant mothers need to consult their doctors before using because some studies on mice have brought out adverse effects on the offspring.
One research study reported 33 minor adverse effects. All of the participants in this study were taking Oxiracetam to treat their Alzheimer’s. No major adverse effects or deaths have so far been reported with this supplement.
Oxiracetam is considered to be more potent than Piracetam. The recommended dosage is between 1200 mg and 2400 mg a day depending upon age and the tolerance levels of the individuals. As with Piracetam, tolerance is very low but can still build up in your system over-time