What is the best nootropic for anxiety? Can nootropics even help with anxiety? We will attempt to answer both questions and try to give the most qualified answer based on our experiences. Nootropics, help your brain with many different tasks and managing anxiety is often one of them.
Perhaps the most interesting in the neuro-transmitting actions of racetams, are the effects they have on the glutamate receptors. Glutamate is the most abundant neurotransmitter in the body and is responsible for the formation of GABA. GABA is the bodys’ most predominant anti-anxiety neurotransmitter. How each racetam interacts with the Glutamate varies but the mechanisms of action are likely to be similar. Although we know that all racetams act with Glutamate receptors to produce GABA we do not understand why one nootropic is more effective than another.
GABA and Anxiety
GABA is an inhibitory neurotransmitter. GABA production and activation is responsible in almost every sedative including: alcohol, benzodiazepines, hypnotics, barbituates. GABA and its actions are responsible for depressing the central nervous system and hence, lowering anxiety. Most psychiatrists and doctors agree, that chemistry based anxiety stems from both, serotonin or GABA issues.
Each and every drug that affects the GABA system will cause different results. Some increase GABA production and some increase how GABA is absorbed in the synaptic process. There are two types of GABA receptors as well, the GABA-a and GABA-b. Both these sites have different functions and effects but activity in either receptor side will generally have calming outputs.
Phenibut for anxiety
Our first look at a nootropic racetam for helping with anxiety is Phenibut. Phenibut is considered a nootropic because it possesses some neurological enhancing and protection functions. In some countries it is sold as a drug, but in North America is can be obtained as a supplement. Phenibut is a derivative of natural occurring GABA that was modified to cross the blood brain barrier (if you don`t already know pure GABA cannot cross the blood brain barrier).
If you have heard of Phenibut you are likely to have heard of its sedative effects as well. A recommended dose is 300mg, but users have reported up to 6 grams being used (we advise you not to take this much.). Naturally, Phenibut works on the GABA-b receptor sites which results in lowered inhibitions and sedation. Effects in higher doses are compared to benzodiazepines and alcohol.
Phenibut has by far the most sedative and anti-anxiety effects of all the nootropics but unfortunately, it also has the most side effects and warnings. Driving or operating equipment on Phenibut is dangerous and possibly illegal. Also mixing Phenibut with other GABAerics like alcohol can be extremely dangerous. Tolerance is another issue with Phenibut and it is not a supplement that should be used every day. Using it every day can result in a huge tolerance build up and can cause withdrawl problems in the future. Phenibut withdrawl has been compared to benzodiazepine withdrawl by some users.
Phenibut can be a great nootropic for treating anxiety once in a while if used responsibly. It was very effective but in no way should it become part of you nootropic daily regimen or stack. This supplement can be an effective tool in relieving short periods of anxiety and stress and should be used on a as per needed basics.
Picamilon for anxiety
Picamilon is another non-racetam nootropic coined as possible in treating anxiety. It is pure GABA that has been modified to cross the blood brain barrier. In Russia it is a registered drug to treat a host of conditions including anxiety and depression. Even though this substance is pure GABA there is little to no sedative effects.
Results with Picamilon vary from person to person. Some find it completely in-effective where as others see it as a miracle supplement for their anxiety. Many people feel that people getting results from Picamilon may be under the placebo effect. It is known however, that you don’t necessarily need to be sedated to have anti-anxiety benefits. Users of Picamilon generally report a very mild stimulated calmness or a very subtle relaxing state. Picamilon is really worth a try for anyone suffering with anxiety. It has much less side effects than Phenibut and tolerance is much lower.
Racetams for Anxiety
Some racetams have been very effective in treating anxiety. All of the racetams are worth a try but Aniracetam has been under the spot light for having very great anti-anxiety effects. Oxiracetam is another great supplement that has been proven to have results for anxiety. All of the racetam family has had reports of helping anxiety however trying the above two is a good start. If you experience no effects with one supplement, move to the next because it could be much more effective for you.
Another newer supplement on the market shown to be effective for anxiety is Noopept.Technically, it is not a racetam but closely related. It is very potent and many people have claimed high anti-anxiety results from its use.